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Healing of hyaluronic acid-enriched wounds: Histological observations

Authors
Journal
Journal of Surgical Research
0022-4804
Publisher
Elsevier
Publication Date
Volume
35
Issue
5
Identifiers
DOI: 10.1016/0022-4804(83)90030-6
Disciplines
  • Biology
  • Medicine

Abstract

Abstract The influence of an exogenous supply of Na hyaluronate (HA) on the healing of superficial skin wounds in healthy and alloxan-induced diabetic rats was histologically assessed. Rats were treated by topical application on the wound site of a 2% Na hyaluronate solution. A facilitating effect of the HA-enrichment on wound repair processes (particularly epithelial migration and differentiation) was markedly evident in wounded diabetic rats. This result is discussed in terms of a possible favorable influence of an HA-enriched wound environment on cell migratory processes occurring during wound healing.

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