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High-throughput methods for the development of new catalytic asymmetric reactions

Authors
Journal
Drug Discovery Today
1359-6446
Publisher
Elsevier
Publication Date
Volume
7
Issue
19
Identifiers
DOI: 10.1016/s1359-6446(02)02436-4
Keywords
  • Research Focus
Disciplines
  • Pharmacology

Abstract

Abstract Chiral, single enantiomer pharmaceuticals have become increasingly more important. Therefore, research aimed at providing new methods for their selective preparation has taken on an even greater importance. One of the most efficient strategies for the synthesis of non-racemic, chiral molecules is asymmetric catalysis. There are many variables involved in the discovery of a new catalytic asymmetric transformation; hence, methods for the rapid screening of large numbers of catalysts have been developed. Herein, these techniques and strategies for the rapid discovery of novel asymmetric catalysts are reviewed.

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