Affordable Access

Publisher Website

Parathyroid hormone responses to the dopaminergic agonist 2-amino-6, 7- dihydroxy-1,2,3,4-tetrahydronaphthalene

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
35
Issue
14
Identifiers
DOI: 10.1016/0024-3205(84)90163-2

Abstract

Abstract Plasma parathyroid hormone (PTH) responses to the dopaminergic agonist 2-amino-6,7-(OH) 2-1,2,3,4-tetrahydronaphthalene (ADTN) have been studied in cattle. During ADTN infusions PTH increased within min in a dose-dependent manner, while calcium remained unchanged. Prolonged administration of ADTN caused transient PTH responses and crosstachyphylaxis to the subsequent administration of the β-adrenergic agonist isoproterenol, but not to hypocalcemia, caused by infusions of ethylene-glycol-bis (β-aminoethylether)-N,N'-tetraacetate. PTH responses were not modified by the β-adrenergic blocking agent propranolol, infused in amounts earlier shown to suppress PTH responses to isoproterenol and epinephrine. In conclusion, the dopaminergic agonist ADTN caused a direct and transient stimulation of PTH secretion, not mediated by hypocalcemia or by β-adrenergic receptors on parathyroid cells. However, crosstachyphylaxis to isoproterenol, but not to hypocalcemia, was observed.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments