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Parathyroid hormone responses to the dopaminergic agonist 2-amino-6, 7- dihydroxy-1,2,3,4-tetrahydronaphthalene

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
35
Issue
14
Identifiers
DOI: 10.1016/0024-3205(84)90163-2

Abstract

Abstract Plasma parathyroid hormone (PTH) responses to the dopaminergic agonist 2-amino-6,7-(OH) 2-1,2,3,4-tetrahydronaphthalene (ADTN) have been studied in cattle. During ADTN infusions PTH increased within min in a dose-dependent manner, while calcium remained unchanged. Prolonged administration of ADTN caused transient PTH responses and crosstachyphylaxis to the subsequent administration of the β-adrenergic agonist isoproterenol, but not to hypocalcemia, caused by infusions of ethylene-glycol-bis (β-aminoethylether)-N,N'-tetraacetate. PTH responses were not modified by the β-adrenergic blocking agent propranolol, infused in amounts earlier shown to suppress PTH responses to isoproterenol and epinephrine. In conclusion, the dopaminergic agonist ADTN caused a direct and transient stimulation of PTH secretion, not mediated by hypocalcemia or by β-adrenergic receptors on parathyroid cells. However, crosstachyphylaxis to isoproterenol, but not to hypocalcemia, was observed.

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