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4-Hydroxyacetophenone-induced choleresis in rats is mediated by the Mrp2-dependent biliary secretion of its glucuronide conjugate.

Authors
  • Mahagita, Chitrawina
  • Tanphichai, Khwanchit
  • Suksamrarn, Apichart
  • Ballatori, Nazzareno
  • Piyachaturawat, Pawinee
Type
Published Article
Journal
Pharmaceutical research
Publication Date
Nov 01, 2006
Volume
23
Issue
11
Pages
2603–2610
Identifiers
PMID: 17009103
Source
Medline
License
Unknown

Abstract

These results demonstrate that the major biliary metabolite of 4-HA in rats is the 4-O-beta-glucuronide, a compound that is secreted into bile at high concentrations, and may thus account in large part for the choleretic effects of 4-HA. Transport of this metabolite across the canalicular membrane into bile requires expression of the Mrp2 transport protein.

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