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4α-Methylated steroids with cytotoxic activity from the soft coral Litophyton mollis.

Authors
  • Zovko Končić, Marijana1
  • Ioannou, Efstathia2
  • Sawadogo, Wamtinga Richard3
  • Abdel-Razik, Ayman F4
  • Vagias, Constantinos2
  • Diederich, Marc5
  • Roussis, Vassilios6
  • 1 Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb 10000, Croatia. , (Greece)
  • 2 Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece. , (Greece)
  • 3 Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC), Luxembourg. , (Luxembourg)
  • 4 Natural Products Chemistry Department, National Research Center, Dokki, Cairo 12622, Egypt. , (Egypt)
  • 5 Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC), Luxembourg; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea. , (North Korea)
  • 6 Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece. Electronic address: [email protected] , (Greece)
Type
Published Article
Journal
Steroids
Publication Date
Nov 01, 2016
Volume
115
Pages
130–135
Identifiers
DOI: 10.1016/j.steroids.2016.08.017
PMID: 27553729
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Seven new (1-3, 5 and 8-10) and three previously reported (4, 6 and 7) 4α-methylated steroids were isolated from the organic extract of the gorgonian Litophyton mollis. The structures and the relative configurations of the isolated natural products were determined on the basis of extensive analyses of their NMR and MS data. Metabolites 1 and 5-8 exhibited cytotoxic activity against K562 human chronic myelogenous leukemia cells with IC50 values below 10μM, while at the same time displaying low toxicity against healthy PBMCs. Copyright © 2016 Elsevier Inc. All rights reserved.

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