Abstract Sixty cases of Hodgkin's disease, sixteen of which came to autopsy, have been observed and an analysis has been made of the commoner subjective and objective clinical findings and the postmortem lesions. Signs referable to the respiratory system and the finding of mediastinal lymphadenopathy were surprisingly common. Hypotension, fever at some time in the disease, tachycardia and an increase in the basal metabolic rate were frequently noted. The blood findings were similar to those described by Bunting as characteristic of the disease. Marked relative and absolute lymphopenia were common as the disease progressed. High voltage roentgen therapy relieved symptoms in most of the treated cases. This series did not permit conclusions relative to prolongation of life as a result of irradiation except in rare instances when the therapy brought about diminution in the size of nodes that were producing mechanical obstruction which appeared to be incompatible with life.