Affordable Access

Publisher Website

PCDH10 is required for the tumorigenicity of glioblastoma cells

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Volume
444
Issue
1
Identifiers
DOI: 10.1016/j.bbrc.2013.12.138
Keywords
  • Protocadherin Pcdh10
  • Ol-Protocadherin
  • Glioblastoma
  • Tumorigenicity
  • Proliferation
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Protocadherin10 (PCDH10)/OL-protocadherin is a cadherin-related transmembrane protein that has multiple roles in the brain, including facilitating specific cell–cell connections, cell migration and axon guidance. It has recently been reported that PCDH10 functions as a tumor suppressor and that its overexpression inhibits proliferation or invasion of multiple tumor cells. However, the function of PCDH10 in glioblastoma cells has not been elucidated. In contrast to previous reports on other tumors, we show here that suppression of the expression of PCDH10 by RNA interference (RNAi) induces the growth arrest and apoptosis of glioblastoma cells in vitro. Furthermore, we demonstrate that knockdown of PCDH10 inhibits the growth of glioblastoma cells xenografted into immunocompromised mice. These results suggest that PCDH10 is required for the proliferation and tumorigenicity of glioblastoma cells. We speculate that PCDH10 may be a promising target for the therapy of glioblastoma.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

PCDH10 is required for the tumorigenicity of gliob...

on Biochemical and Biophysical Re... Jan 31, 2014

PCDH10 is a candidate tumour suppressor gene in me...

on Child's nervous system : ChNS... August 2011
More articles like this..