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Cytotoxic T-Lymphocyte Associated Antigen 4 Polymorphisms and Asthma Risk: A Meta-Analysis

Authors
Journal
PLoS ONE
1932-6203
Publisher
Public Library of Science
Publication Date
Volume
7
Issue
7
Identifiers
DOI: 10.1371/journal.pone.0042062
Keywords
  • Research Article
  • Biology
  • Genetics
  • Population Genetics
  • Genetic Polymorphism
  • Immunology
  • Immune Cells
  • T Cells
  • Medicine
  • Clinical Research Design
  • Meta-Analyses
  • Pulmonology
  • Asthma
  • Science Policy
  • Research Assessment

Abstract

Background A number of studies assessed the association of cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) gene polymorphisms with asthma in different populations. However, the results were contradictory. We performed a meta-analysis to examine the association between CTLA-4 polymorphisms and asthma susceptibility. Methods Pubmed, EMBASE, HuGE Navigator, and Wanfang Database were searched. Data were extracted independently by two reviewers. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Results Seventeen studies involving 6378 cases and 8674 controls were included. Significant association between +49 A/G polymorphism and asthma was observed for AA vs. AG+GG (OR = 1.18, 95% CI 1.01–1.37, P = 0.04). There were no significant associations between −318 C/T, −1147 C/T, CT60 A/G, −1722 C/T, or rs926169 polymorphisms and asthma risk. Conclusions This meta-analysis suggested that the +49 A/G polymorphism in CTLA-4 was a risk factor for asthma.

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