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Effect of phonophoretic application of diclofenac gel on localized musculoskeletal disorders

Authors
Journal
Current Therapeutic Research
0011-393X
Publisher
Elsevier
Publication Date
Volume
55
Issue
11
Identifiers
DOI: 10.1016/s0011-393x(05)80323-6

Abstract

Abstract The objective of this study was to assess the efficacy and tolerability of the phonophoretic application of diclofenac gel TM in patients with localized musculoskeletal disorders. Sixty-seven consenting patients were randomly assigned to receive ultrasound treatment using either Aquasonic ® 100 (32 patients) or diclofenac gel (35 patients) as the ultrasound coupling agent. Each group received ultrasound treatments of 1.5 W/cm 2 for 15 minutes three times per week for 3 weeks. Both groups showed significant improvement in all the criteria evaluated. Twenty-four (68.6%) patients in the diclofenac gel group and 16 (50%) patients in the Aquasonic 100 group discontinued treatment early. Of these patients, 14 (58.3%) in the diclofenac gel group and 6 (37.5%) in the Aquasonic 100 group discontinued treatment early because they were considered cured. This occurred earlier in the diclofenac gel group (5.3 ± 1.8 vs 6.7 ± 1.4 sessions; P = 0.054) and resulted in 52 fewer sessions in the diclofenac gel group and 14 fewer in the Aquasonic 100 group. The treatment was well tolerated, with only minor local side effects. These results suggest that phonophoretic application of diclofenac gel is well tolerated and results in an early cure in a substantial proportion of patients with localized musculoskeletal disorders.

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