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Influence of Laminarin polysaccahrides on oxidative damage

Authors
Journal
International Journal of Biological Macromolecules
0141-8130
Publisher
Elsevier
Publication Date
Volume
48
Issue
1
Identifiers
DOI: 10.1016/j.ijbiomac.2010.09.011
Keywords
  • Laminarin Polysaccharides
  • Gc–Ms
  • Chemical Analysis
  • Sod
  • Gpx
  • Oxidative Stress
Disciplines
  • Medicine

Abstract

Abstract Laminarin is a tropical plant traditionally used in Chinese medicine. In this experiment, Laminarin polysaccharides were analysed using GC–MS method and result showed that the polysaccharides contained mannose (3.27%), arabinose (8.61%), glucose (4.23%), galactose (12.12%), fucose (46.93%). Laminarin polysaccharides were tested to evaluate their effect on lung oxidative stress and lipid peroxidation in rats. The animal were divided into model and polysaccharides-treated animal. Laminarin polysaccharides were administered by gavage over a 14-day period. The results indicated that Laminarin polysaccharides significantly normalized catalase (CAT) activity ( P < 0.01), increased glutathione peroxidase (GPx) activity ( P < 0.05), superoxide dismutase (SOD) activity and reduced malondialdehyde (MDA) concentrations in animal. It could be concluded that Laminarin polysaccharides appeared to be more effective in reducing sepsis-induced oxidative stress, lipid peroxidation in animal.

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