We examined a 33-year-old woman with a week long history of a progressively inflamed left eye who showed oculoglandular conjunctivitis and a marginal corneal ulcer. Three days later she presented with fever and cutaneous maculopapular exanthema. The patient revealed that 2 weeks earlier a jet of blood had splashed into her left eye as she accidentally crushed a tick on her dog. Blood samples from the patient were positive to the Weil–Felix test; therefore, Mediterranean spotted fever was diagnosed. Systemic and topical treatment with tetracyclines was successful. The possibility that spotted fever may be acquired through the eye should be kept in mind.