Abstract Since boron has been showing to induce male reproductive impediments in laboratory animals, the 1993 WHO guidelines for drinking water quality set the recommended guideline value at 0.3 mg boron/l based on the NOEL (no-observed-adverse-effect level). Since boron is not effectively removed by the conventional water treatment not only for drinking water and domestic wastewater treatment, the concentration in ambient water as well as drinking water is affected by its consumption such as for soaps and detergents in the catchment area. Boron is also affected by leaching from the surrounding geology, drinking water derived water sources affected by a weak alkali spring contains high level of boron. Since the rejection ratio of boron is extremely less than that of salts in RO membrane system applying to drinking water supply in the areas where scarce a fresh water resources, desalinated water contains higher level of boron than that of WHO drinking water quality guidelines. In order to develop of boron treatment system either fresh water or desalinated water, multi stage RO membrane treatment system has studied by using a pilot plant. The boron rejection of RO membrane depends greatly upon pH and driving pressure of RO process. However, the boron rejection does not depends upon its concentration of raw water. Therefore, it is necessary to apply multi stage RO membrane treatment system for producing a finished water that meets the WHO drinking water quality guideline level of boron. Since the secondary and third RO membrane treat less dissolved salt concentration such as observed in fresh water, the driving pressure of RO process for removing boron can operate at low pressure such as about 0.6 to 1.3 MPa. Therefore, multi stage RO membrane sea desalination process and a low pressure RO process can be recommendable for boron management with a reasonable additional cost in drinking water supply.