Affordable Access

Publisher Website

Ultrastructural pathology of nephropathies with organized deposits: a case series

Cases Journal
Springer (Biomed Central Ltd.)
Publication Date
DOI: 10.1186/1757-1626-1-184
  • Case Report
  • Biology
  • Medicine

Abstract ral ss BioMed CentCases Journal Open AcceCase Report Ultrastructural pathology of nephropathies with organized deposits: a case series Fabio Fabbian*1, Nevio Stabellini1, Adriana Galdi1, Sergio Sartori2, Arrigo Aleotti3 and Luigi Catizone1 Address: 1Renal Unit, St. Anna Hospital, Corso Giovecca 203, 44100 Ferrara, Italy, 2Internal Medicine, St. Anna Hospital, Corso Giovecca 203, 44100 Ferrara, Italy and 3Electron Microscopy Service, University of Ferrara, Via Savonarola 9, 44100 Ferrara, Italy Email: Fabio Fabbian* - [email protected]; Nevio Stabellini - [email protected]; Adriana Galdi - [email protected]; Sergio Sartori - [email protected]; Arrigo Aleotti - [email protected]; Luigi Catizone - [email protected] * Corresponding author Abstract Renal organized or structured deposits are much less frequent than those with usual type immunocomplex deposits and are encountered in a wide variety of primary and systemic disorders. It has been suggested that immunoglobulins (Igs) are responsible for organized deposits. We report 5 cases who have been diagnosed and treated in our hospital. Patients were aged 52 to 72 years, three of them were males and had variable degree of renal function, from normal serum creatinine to uraemia. Proteinuria was detected in all patients while monoclonal component was present only in the serum of one subject. Ultrastructural analysis of renal specimens revealed organized deposits. Diagnoses that were made are the following: membranoproliferative glomerulonephritis with finger print, immunotactoid glomerulopathy, membranoproliferative glomerulonephritis with arched deposits, primary amyloidosis and light chain deposition disease. In systemic disorders ultrastructural pathology could be particularly valuable for correct deposits classification, precise localization and pattern of deposition of Igs. Introduction Differential diagnosis of renal organized or structured deposits is a matter of debate [1]. They are much less fre- quent than tho

There are no comments yet on this publication. Be the first to share your thoughts.