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Human peritoneal macrophage activity is increased by tuftsin

Authors
Journal
Immunology Letters
0165-2478
Publisher
Elsevier
Publication Date
Volume
21
Issue
3
Identifiers
DOI: 10.1016/0165-2478(89)90113-2
Keywords
  • Tuftsin
  • Peritoneal Macrophages
  • Superoxide Production
  • Candida Association
Disciplines
  • Medicine

Abstract

Abstract Peritonitis caused by Candida albicans is a major complication of continuous ambulatory peritoneal dialysis (CAPD). Increasing the activity of the peritoneal macrophages- the predominant cell type found in the peritoneal cavity-may be of great importance in the prevention and therapy of peritonitis. Therefore, the activating effect of tuftsin was studied on human peritoneal macrophages from CAPD patients. Tuftsin induced a biphasic effect on macrophage activity within a range of 2×10 − 9-2×10 − 6M, with a maximal activity 2×10 − 7M. At this concentration,tuftsin enhanced by twofold cell association with radiolabelled candida (from 2±0.2 to 4±0.2 candida per macrophage) and superoxide anion production in response to exposure to candida (from 150±20 to 300±20 nmoles/mg). These results suggest the potential use of tuftsin as a therapeutic drug.

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