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Pathogenesis of Exercise-Induced Bronchoconstriction

Authors
Journal
Immunology and Allergy Clinics of North America
0889-8561
Publisher
Elsevier
Volume
33
Issue
3
Identifiers
DOI: 10.1016/j.iac.2013.02.002
Keywords
  • Hyperpnoea
  • Osmotic Stress
  • Thermal Stress
  • Epithelial Injury
  • Airway Inflammation
Disciplines
  • Biology

Abstract

This article presents the various potential mechanisms responsible for the development of exercise-induced bronchoconstriction (EIB). Although the etiology of EIB is multifactorial, and the physiologic processes involved may vary between individuals (especially between those with and without asthma), drying of the small airways with an associated inflammatory response seems prerequisite for EIB. Dysregulated repair processes following exercise-induced airway epithelial injury may also serve as basis for EIB development/progression.

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