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The surface of α-subunit loop 1 distant from the subunit interface is exposed in the hCG lutropin receptor complex

Authors
Journal
Biochimica et Biophysica Acta (BBA) - General Subjects
0304-4165
Publisher
Elsevier
Publication Date
Volume
1475
Issue
3
Identifiers
DOI: 10.1016/s0304-4165(00)00097-0
Keywords
  • Hcg
  • Lutropin Receptor
  • Hcg–Receptor Complex
  • Hcg Structure/Function
  • Hcg Antibody
Disciplines
  • Biology

Abstract

Abstract Interactions of the placental glycoprotein hormone human choriogonadotropin (hCG) with lutropin receptors (LHR) are required for maintenance of early pregnancy. Knowledge of how hCG interacts with LHR is useful for understanding the mechanism of receptor function, an issue of considerable debate. A large surface of hCG remains exposed after the hormone binds the LHR and can be readily detected with monoclonal antibodies. Here we show that the surface of hCG α-subunit loop 1 furthest from the β-subunit interface can also be recognized by a monoclonal antibody when hCG is bound to the LHR. This extends the area of hCG known to be exposed in the hormone receptor complex, an observation that further restricts models of hCG–LHR interaction.

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