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Successful Long-Term Use of Infliximab in Refractory Pouchitis in an Adolescent

Authors
Journal
Gastroenterology Research and Practice
1687-6121
Publisher
Hindawi Publishing Corporation
Publication Date
Volume
2010
Identifiers
DOI: 10.1155/2010/860394
Keywords
  • Case Report
Disciplines
  • Medicine

Abstract

Pouchitis is a common complication that develops after an ileal pouch-anal anastomosis after colectomy for ulcerative colitis. In some cases, pouchitis becomes chronic and refractory to conventional therapies including antibiotics, corticosteroids, immunomodulators, probiotics, and anti-inflammatory drugs. We report a case of an adolescent with chronic pouchitis who not only improved with infliximab therapy but remains in long-term remission with maintenance therapy without any adverse effects. Infliximab is a safe and effective therapy for refractory pouchitis and may obviate the need for pouch removal and a permanent ileostomy.

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