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Transcriptional regulation of human small nuclear RNA genes

Authors
Journal
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
1874-9399
Publisher
Elsevier
Publication Date
Volume
1779
Issue
5
Identifiers
DOI: 10.1016/j.bbagrm.2008.04.001
Keywords
  • Human Snrna Gene
  • Transcription
  • Retinoblastoma Protein
  • P53 Tumor Suppressor
  • Rna Polymerase Ii
  • Rna Polymerase Iii

Abstract

Abstract The products of human snRNA genes have been frequently described as performing housekeeping functions and their synthesis refractory to regulation. However, recent studies have emphasized that snRNA and other related non-coding RNA molecules control multiple facets of the central dogma, and their regulated expression is critical to cellular homeostasis during normal growth and in response to stress. Human snRNA genes contain compact and yet powerful promoters that are recognized by increasingly well-characterized transcription factors, thus providing a premier model system to study gene regulation. This review summarizes many recent advances deciphering the mechanism by which the transcription of human snRNA and related genes are regulated.

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