Marine emissions of nitrous oxide (N2O) supply ~10-30% of the annual N2O flux to the atmosphere, affecting both climate and stratospheric ozone. Low oxygen regions of the eastern tropical Pacific (ETP) supply much of open ocean N2O. However, due to this region's sensitivity to future climate change, future N2O emissions from the ETP are highly uncertain, although previous short-term responses to ENSO events indicate that N2O is sensitive to changes in oxygen. Here, we use global biogeochemistry-circulation models to assess uncertainties in projected current and future N2O emissions from the ETP to the atmosphere. Our work includes a comparison between previous model descriptions of marine N2O and a newly developed data based parameterization of N2O production and consumption.