Abstract An ethylene glycol solution of Ca(OAC) 2. xH 2O and a butanol solution of P 2O 5 were used as precursors to produce hydroxyapatite. Acetic acid (HOAC) and ammonium nitrate (NH 4NO 3) acted as a stabilizer and an oxidizer, respectively, during the process. A stable mixed solution of the two precursors could be obtained by adding acetic acid in the HOAC Ca ratio of 2. As-prepared powders were obtained by pouring the mixed solution into a hot plate to evaporate the solvents. A poorly crystallized hydroxyapatite phase was obtained from the as-prepared powders after calcination at 500 °C, where a dark powder was formed. Calcination at 1000 °C gave white powders having a well-crystallized hydroxyapatite phase with a small amount of CaO. When NH 4NO 3 was added to the stable mixed solution before pouring into the hot plate, the as-prepared powders calcined at 500 °C were white and composed of wellcrystallized hydroxyapatite with a small amount of β-tricalcium phosphate. The hydroxyapatite obtained in this work is a nonstoichiometric calcium-deficient material, Ca 10 − x (HPO 4) x (PO 4) 3 − x (OH). The described route to synthesize hydroxyapatite has potential applications for the preparation of hydroxyapatite coatings.