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Differential Modulatory Effects of Clarithromycin on the Production of Cytokines by a Tumor

Authors
Publisher
American Society for Microbiology
Publication Date
Source
PMC
Keywords
  • Mechanisms Of Action: Physiological Effects
Disciplines
  • Biology

Abstract

In vitro treatment with clarithromycin inhibited the expression of the matrix metalloproteinase-9, transforming growth factor β, and tumor necrosis factor alpha genes in 13762NF rat mammary adenocarcinoma cells. Transient enhancement, rather than inhibition, was observed for the interleukin-6 gene, and no significant change was observed for the tissue inhibitor of metalloproteinase-2 gene. Such an effect was not observed for cefotiam or gentamicin.

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