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The effects of morphine on carrageenin-induced spinal c-Fos expression are completely blocked by β-funaltrexamine, a selective μ-opioid receptor antagonist

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
732
Identifiers
DOI: 10.1016/0006-8993(96)00749-4
Keywords
  • Antinociception
  • C-Fos
  • Spinal Cord
  • Morphine
  • Carrageenin
  • μ-Opioid Receptor
  • β-Funaltrexamine

Abstract

Abstract We have demonstrated that pre-administered morphine (3 mg/kg, i.v.) decreased spinal c-Fos expression induced 2 h after intraplantar carrageenin (55 ± 5% reduction, P < 0.0001). These effects were completely blocked by pre-administered β-funaltrexamine (10 mg/kg, i.v., 24 h prior to stimulation) a selective long-lasting μ-opioid receptor antagonist. In conclusion, these results clearly demonstrate that the effects of morphine on noxiously-evoked spinal c-Fos expression are essentially mediated via μ-opioid receptors.

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