Affordable Access

Publisher Website

Roles of thioredoxin binding protein (TXNIP) in oxidative stress, apoptosis and cancer

Authors
Journal
Mitochondrion
1567-7249
Publisher
Elsevier
Volume
13
Issue
3
Identifiers
DOI: 10.1016/j.mito.2012.06.004
Keywords
  • Apoptosis
  • Txnip/Vdup-1/Tbp-2
  • Reactive Oxygen Species (Ros)
  • Oxidative Stress
  • Solid Tumor
  • Leukemia
Disciplines
  • Biology

Abstract

Abstract Thioredoxin binding protein (TXNIP) has multiple functions and plays an important role in redox homeostasis. TXNIP increases the production of reactive oxygen species (ROS), and oxidative stress, resulting in cellular apoptosis. It has been identified as a tumor suppressor gene (TSG) in various solid tumors and hematological malignancies. In the present review, we will first provide an overview of TXNIP protein and function, followed by a summary of the major studies that have demonstrated the frequent repression of TXNIP in cancers. Functional characterization of TXNIP knockout mouse model is summarized. We will then discuss the use of small molecular inhibitors to reactivate TXNIP expression as a novel anticancer strategy.

There are no comments yet on this publication. Be the first to share your thoughts.