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Integrating binary traits with quantitative phenotypes for association mapping of multivariate phenotypes

Authors
Journal
BMC Proceedings
1753-6561
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
5
Identifiers
DOI: 10.1186/1753-6561-5-s9-s73
Keywords
  • Proceedings

Abstract

Clinical binary end-point traits are often governed by quantitative precursors. Hence it may be a prudent strategy to analyze a clinical end-point trait by considering a multivariate phenotype vector, possibly including both quantitative and qualitative phenotypes. A major statistical challenge lies in integrating the constituent phenotypes into a reduced univariate phenotype for association analyses. We assess the performances of certain reduced phenotypes using analysis of variance and a model-free quantile-based approach. We find that analysis of variance is more powerful than the quantile-based approach in detecting association, particularly for rare variants. We also find that using a principal component of the quantitative phenotypes and the residual of a logistic regression of the binary phenotype on the quantitative phenotypes may be an optimal method for integrating a binary phenotype with quantitative phenotypes to define a reduced univariate phenotype.

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