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The Intrathymic Pathogenesis of Myasthenia Gravis

Authors
Publisher
Hindawi Publishing Corporation
Publication Date
Volume
11
Identifiers
DOI: 10.1080/17402520400001769
Keywords
  • Research Article
Disciplines
  • Medicine

Abstract

The thymus is considered to play an important role in the pathogenesis of Myasthenia gravis, an autoimmune disease characterized by antibody-mediated skeletal muscle weakness. However, its role is yet to be defined. The studies described herein summarize our efforts to determine how intrathymic expression of the neuromuscular type of acetylcholine (ACh) receptors is involved in the immunopathogenesis of this autoimmune disease. We review the work characterizing the expression of neuromuscular ACh receptors in the thymus and advance a new hypothesis that examines the intrathymic expression of this autoantigen in disease pathogenesis.

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