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Argonaute Proteins: Mediators of RNA Silencing

Authors
Journal
Molecular Cell
1097-2765
Publisher
Elsevier
Publication Date
Volume
26
Issue
5
Identifiers
DOI: 10.1016/j.molcel.2007.05.001
Keywords
  • Rna
Disciplines
  • Biology

Abstract

Summary Small regulatory RNAs such as short interfering RNAs (siRNAs), microRNAs (miRNAs), and Piwi interacting RNAs (piRNAs) have been discovered in the past, and it is becoming more and more apparent that these small molecules have key regulatory functions. Small RNAs are found in all higher eukaryotes and play important roles in cellular processes as diverse as development, stress response, or transposon silencing. Soon after the discovery of small regulatory RNAs, members of the Argonaute protein family were identified as their major cellular protein interactors. This review focuses on the various cellular functions of mammalian Argonaute proteins in conjunction with the different small RNA species that are known today.

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