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A structural analysis of the TOB complex, the insertase for Beta-barrel proteins of the mitochondrial outer membrane

Authors
Publisher
Ludwig-Maximilians-Universität München
Publication Date
Keywords
  • Fakultät Für Biologie
Disciplines
  • Biology

Abstract

Structural and Functional Analysis of the TOB complex ii iii iv 1 INTRODUCTION ....................................................................................................................................... 1 1.1 MITOCHONDRIA ............................................................................................................................................ 1 1.2 PROTEIN TRANSLOCATION INTO MITOCHONDRIA .................................................................................................. 4 1.2.1 The TOM complex ............................................................................................................................ 6 1.2.2 Import of proteins into the matrix ................................................................................................... 7 1.2.3 Import of proteins into the inner mitochondrial membrane ........................................................... 9 1.2.4 Import of proteins into the intermembrane space ........................................................................ 12 1.2.5 Import of proteins into the outer mitochondrial membrane ......................................................... 12 1.3 THE TOB COMPLEX ...................................................................................................................................... 15 1.3.1 Introduction ................................................................................................................................... 15 1.3.2 Composition of the TOB complex .................................................................................................. 15 1.3.3 Topogenesis of mitochondrial ß-barrel proteins ......................................................................

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