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Electroorganic chemistry 139. Electroreductive decyanation of nitriles and its application to synthesis of α-alkylamines

Authors
Journal
Tetrahedron
0040-4020
Publisher
Elsevier
Publication Date
Volume
48
Issue
38
Identifiers
DOI: 10.1016/s0040-4020(01)80493-2

Abstract

Abstract Electroreduction of nitriles gave the corresponding decyanated products when Zn was used as the material of cathode in aprotic solvent (DMF or MeCN) containing Et 4NOTs as a supporting electrolyte. Alkylation of amines at the α-position was effectively achieved by cyanation of amines at the α-position, and α-alkylation of the resultant α-amino nitriles followed by the electroreductive decyanation.

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