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3D Cell Printing of Tissue/Organ-Mimicking Constructs for Therapeutic and Drug Testing Applications

Authors
  • Kim, Jongmin
  • Kong, Jeong Sik
  • Han, Wonil
  • Kim, Byoung Soo
  • Cho, Dong-Woo1
  • 1 Institute of Convergence Science, Yonsei University, Seoul 03722, Korea
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
Oct 20, 2020
Volume
21
Issue
20
Identifiers
DOI: 10.3390/ijms21207757
PMID: 33092184
PMCID: PMC7589604
Source
PubMed Central
Keywords
Disciplines
  • Review
License
Green

Abstract

The development of artificial tissue/organs with the functional maturity of their native equivalents is one of the long-awaited panaceas for the medical and pharmaceutical industries. Advanced 3D cell-printing technology and various functional bioinks are promising technologies in the field of tissue engineering that have enabled the fabrication of complex 3D living tissue/organs. Various requirements for these tissues, including a complex and large-volume structure, tissue-specific microenvironments, and functional vasculatures, have been addressed to develop engineered tissue/organs with native relevance. Functional tissue/organ constructs have been developed that satisfy such criteria and may facilitate both in vivo replenishment of damaged tissue and the development of reliable in vitro testing platforms for drug development. This review describes key developments in technologies and materials for engineering 3D cell-printed constructs for therapeutic and drug testing applications.

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