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Detection of botulinum neurotoxins in buffer and honey using a surface plasmon resonance (SPR) sensor

Authors
Journal
Sensors and Actuators B Chemical
0925-4005
Publisher
Elsevier
Publication Date
Volume
130
Issue
1
Identifiers
DOI: 10.1016/j.snb.2007.07.140
Keywords
  • Surface Plasmon Resonance (Spr)
  • Botulinum Neurotoxin
  • Sensor

Abstract

Abstract At least three botulinum neurotoxin serotypes, A, B and F, have been implicated in cases of human botulism. The work presented uses a custom-built SPR biosensor to detect each of these three serotypes of neurotoxin in 1 h. Detection curves were established for concentrations of 20 ng/ml and below. The lowest concentration detected for individual toxin samples was either 0.5 or 1 ng/ml for all three serotypes. Detections were also performed on a mixture of all three toxin serotypes in buffer, as well as a 20% honey solution. Detections of mixtures in buffer and in a 20% honey solution complex matrices showed good agreement with detections of individual toxins in buffer.

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