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The effect of oral sodium fluoride on aortic phosphate in experimental atherosclerosis

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
6
Issue
9
Identifiers
DOI: 10.1016/0024-3205(67)90087-2

Abstract

Abstract A preliminary experiment has been performed in which sodium fluoride was fed to a group of rabbits with induced atherosclerosis. Comparison of the aortas of this group to those of an untreated atherosclerotic group shows a sharp drop in the TCA soluble phosphate content toward normal values, a tendency for normalization of phospholipid levels and a trend to regression of the gross, visible atherosclerosis. The hypothesis is posed that these findings are probably mediated through parathyroid activity as has been stipulated elsewhere for the ameliorating effect of MgEDTA on induced atherosclerosis.

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