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Curare-binding macromolecules from medullated nerve tissue

Authors
Journal
Archives of Biochemistry and Biophysics
0003-9861
Publisher
Elsevier
Publication Date
Volume
99
Issue
3
Identifiers
DOI: 10.1016/0003-9861(62)90297-7

Abstract

Abstract Cold water extracts of macerated sciatic nerve tissue from the frog and dog have been fractionated on ion-exchange adsorbents. Key fractions have been characterized with respect to their gradient elution properties, their behavior on ultracentrifugation and disc electrophoresis, and their ability to bind or precipitate with quaternary amine derivatives such as d-tubocurarine ion. The results are discussed in terms of a potential role of these macromolecules as chemoreceptors in the intact tissues.

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