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Strategically functionalized carbon nanotubes as the ultrasensitive electrochemical probe for picomolar detection of sildenafil citrate (Viagra)

Authors
Journal
Biosensors and Bioelectronics
0956-5663
Publisher
Elsevier
Publication Date
Volume
26
Issue
6
Identifiers
DOI: 10.1016/j.bios.2010.12.005
Keywords
  • Sildenafil Citrate
  • 4-Aminobenzene Sulfonic Acid
  • Multiwalled Carbon Nanotubes
  • Drug
  • Electrochemical Method
  • Picomolar
Disciplines
  • Chemistry
  • Design

Abstract

Abstract The present work demonstrates the utility of the functionalized carbon nanotubes, poly(4-aminobenzene sulfonic acid) (PABS) grafted multiwalled carbon nanotubes, MWNT-g-PABS, as an electrode modifier towards achieving ultrasensitive detection of a model drug, sildenafil citrate (SC). PABS units in MWNT-g-PABS interact with SC, pre-concentrate and accumulate at the surface. The electron transduction from SC to electrode is augmented via MWNT-g-PABS. As a result, the MWNT-g-PABS modified electrode exhibited ultrasensitive (57.7μA/nM) and selective detection of SC with a detection limit of 4.7pM. The present work provides scope towards targeting ultrasensitivity for the detection of biomolecules/drug through rational design and incorporation of appropriate chemical components to carbon nanotubes.

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