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Voltammetric determination of 6-mercaptopurine using [Co(phen)3]3+/MWNT modified graphite electrode

Authors
Journal
Journal of Electroanalytical Chemistry
1572-6657
Publisher
Elsevier
Publication Date
Volume
621
Issue
1
Identifiers
DOI: 10.1016/j.jelechem.2008.04.018
Keywords
  • 6-Mercaptopurine
  • Cobalt(Iii) Complex
  • Carbon Nanotubes
  • Modified Electrode
Disciplines
  • Chemistry

Abstract

Abstract [Co(phen) 3] 3+/multi-walled carbon nanotubes modified graphite electrode ([Co(phen) 3] 3+/MWNT/C) has been developed to monitor quantitatively 6-mercaptopurine (6-MP) concentration and to study the effect of rabbit blood as disturbance agents on the determination. Multi-walled carbon nanotubes (MWNT) are used for efficient immobilization of [Co(phen) 3] 3+. The prepared [Co(phen) 3] 3+/MWNT/C electrode exhibits an excellent redox activity. 6-MP is detected by monitoring the reductive current values of free [Co(phen) 3] 3+ or the [Co(phen) 3] 3+–6-MP complex generated by the interaction of [Co(phen) 3] 3+ on the MWNT modified graphite electrode with 6-MP. These electrochemical signals are found to be sensitive enough to monitor 6-MP concentration changes, and the [Co(phen) 3] 3+/MWNT/C electrode has also been applied to the evaluation of 6-MP in the presence of rabbit blood.

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