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Selective GABAAcircuits for novel CNS drugs

Authors
Journal
Drug Discovery Today Therapeutic Strategies
1740-6773
Publisher
Elsevier
Publication Date
Volume
1
Issue
1
Identifiers
DOI: 10.1016/j.ddstr.2004.08.019
Disciplines
  • Biology
  • Pharmacology

Abstract

By controlling spike timing and sculpting neuronal rhythms, inhibitory interneurons play a key role in brain function. GABAergic interneurons are highly diverse. The respective γ-aminobutyric acid (GABA) A receptor subtypes, therefore, provide new opportunities for targeting selective neuronal circuits. In addition, multiple sites for drug interactions are present on GABA A receptor subtypes. Their pharmacological relevance is increasingly being recognized. A new central nervous system (CNS) pharmacology is on the horizon.

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