Affordable Access

Publisher Website

Ventricular dyssynchrony assessed by gated myocardial perfusion SPECT using a geometrical approach: a feasibility study

Authors
Journal
European Journal of Nuclear Medicine and Molecular Imaging
1619-7070
Publisher
Springer-Verlag
Publication Date
Volume
39
Issue
3
Identifiers
DOI: 10.1007/s00259-011-1991-x
Keywords
  • Original Article
Disciplines
  • Mathematics
  • Medicine

Abstract

Purpose Left ventricular dyssynchrony may predict response to cardiac resynchronization therapy and may well predict adverse cardiac events. Recently, a geometrical approach for dyssynchrony analysis of myocardial perfusion scintigraphy (MPS) was introduced. In this study the feasibility of this geometrical method to detect dyssynchrony was assessed in a population with a normal MPS and in patients with documented ventricular dyssynchrony. Methods For the normal population 80 patients (40 men and 40 women) with normal perfusion (summed stress score ≤2 and summed rest score ≤2) and function (left ventricular ejection fraction 55–80%) on MPS were selected; 24 heart failure patients with proven dyssynchrony on MRI were selected for comparison. All patients underwent a 2-day stress/rest MPS protocol. Perfusion, function and dyssynchrony parameters were obtained by the Corridor4DM software package (Version 6.1). Results For the normal population time to peak motion was 42.8 ± 5.1% RR cycle, SD of time to peak motion was 3.5 ± 1.4% RR cycle and bandwidth was 18.2 ± 6.0% RR cycle. No significant gender-related differences or differences between rest and post-stress acquisition were found for the dyssynchrony parameters. Discrepancies between the normal and abnormal populations were most profound for the mean wall motion (p value <0.001), SD of time to peak motion (p value <0.001) and bandwidth (p value <0.001). Conclusion It is feasible to quantify ventricular dyssynchrony in MPS using the geometrical approach as implemented by Corridor4DM.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Left ventricular mechanical dyssynchrony as assess...

on Echocardiography (Mount Kisco,... November 2008

Stress-induced myocardial ischemia is associated w...

on European Journal of Nuclear Me... December 2012

Left ventricular dyssynchrony assessed by two thre...

on European Journal of Nuclear Me... January 2008

Effect of alcohol septal ablation in patients with...

on The International Journal of C... August 2012
More articles like this..