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Fatty acids bounds to serumalbumin decrease the half-life of thromboxane A2

Authors
Journal
Prostaglandins & Other Lipid Mediators
0090-6980
Publisher
Elsevier
Publication Date
Volume
20
Issue
2
Identifiers
DOI: 10.1016/s0090-6980(80)80046-3

Abstract

Abstract The half-life of thromboxane A 2 is increased in plasma as well as in a buffer containing serumalbumin. Moreover, the half-life of thromboxane A 2 depends on the amount of unesterified fatty acids bound to albumin. When more fatty acids are bound, the half-life is shortened. This shortening is accompanied by a decrease of the aggregating activity of thromboxane A 2.

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