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Myocardial couplings: Their structural variations in the mouse

Authors
Journal
Journal of Ultrastructure Research
0022-5320
Publisher
Elsevier
Publication Date
Volume
58
Issue
1
Identifiers
DOI: 10.1016/s0022-5320(77)80007-5

Abstract

In mouse myocardial cells, the sarcoplasmic reticulum (SR) forms specialized complexes (“couplings”) with both the sarcolemma and its extension, the system of transverse (T) and axial (Ax) tubules. As well as contributing to conventional “diads” and “triads,” the junctional region of the SR (J-SR) often forms complexes having special configurations, the latter including: (1) couplings in which J-SR is wrapped partially or completely around T-Ax tubules; (2) “reversed triads” in which a single J-SR saccule is flanked by two T-Ax tubules; (3) “pentad” and “sextad” couplings with multiple J-SR and T-Ax elements; and (4) “bidirectional peripheral couplings” in which J-SR is sandwiched between closely apposed folds of the sarcolemma, a condition frequently observed in the region of the intercalated disc. In the last three configurations, electron-opaque junctional processes are formed on both sides of the flattened sac of J-SR, rather than on a single side as in conventional couplings.

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