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Scaffolds for tissue engineering of cardiac valves

Authors
Journal
Acta Biomaterialia
1742-7061
Publisher
Elsevier
Volume
10
Issue
7
Identifiers
DOI: 10.1016/j.actbio.2014.03.014
Keywords
  • Heart Valve
  • Tissue Engineering
  • Scaffold
  • Fiber
  • Hydrogel
Disciplines
  • Design
  • Engineering
  • Medicine

Abstract

Abstract Tissue engineered heart valves offer a promising alternative for the replacement of diseased heart valves avoiding the limitations faced with currently available bioprosthetic and mechanical heart valves. In the paradigm of tissue engineering, a three-dimensional platform – the so-called scaffold – is essential for cell proliferation, growth and differentiation, as well as the ultimate generation of a functional tissue. A foundation for success in heart valve tissue engineering is a recapitulation of the complex design and diverse mechanical properties of a native valve. This article reviews technological details of the scaffolds that have been applied to date in heart valve tissue engineering research.

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