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The role of X-chromosome inactivation in female predispositionto autoimmunity

Authors
Journal
Arthritis Research
1465-9905
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
3
Issue
3
Identifiers
DOI: 10.1186/ar298
Keywords
  • Erratum
Disciplines
  • Medicine

Abstract

Erratum.qxd Erratum The role of X-chromosome inactivation in female predisposition to autoimmunity Smita Chitnis*, Joanita Monteiro*, David Glass†, Brian Apatoff‡, Jane Salmon§, Patrick Concannon¶ and Peter K Gregersen* *North Shore University Hospital, Manhasset, New York, †Children’s Hospital Medical Center, and University of Cincinnati College of Medicine, Cincinnati, Ohio, ‡New York Hospital/Cornell University Medical Center, New York, §Weill Medical College of Cornell University and Hospital for Special Surgery, New York, and ¶Virginia Mason Research Center, Seattle, Washington, USA Erratum Published: 26 March 2001 It has come to our attention that we overlooked a previous publication in the course of discussing our work (cited above) on X chromosome inactivation and autoimmunity. We proposed a model that is very similar to one put forward in 1977 by Richard Kast [1]. The central concept is that X inactivation patterns in a tolerizing compartment, such as the thymus, may differ from those in the periphery, and this may predispose females to additional risk of autoimmunity. Presumably the loss of tolerance due to this mechanism will be directed at, or initiated by, polymorphic X-linked autoantigens. Our data neither confirm nor definitively refute this idea, and it will be challenging to develop experimental support for this hypothesis. In any case, we apologize for the oversight in not citing Dr Kast's previous publication. 1. Kast RE: Predominance of autoimmune and rheumatic diseases in females. J Rheumatol 1977, 4: 288–292. Arthritis Res 2000, 2:399–406 The electronic version of this article can be found online at http://arthritis-research.com/content/2/5/399 Print ISSN 1465-9905; Online ISSN 1465-9913 http://arthritis-research.com/content/3/3/E001

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