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Minimal residual disease in hypopigmented mycosis fungoides

Authors
Journal
Journal of the American Academy of Dermatology
0190-9622
Publisher
Elsevier
Publication Date
Volume
54
Issue
5
Identifiers
DOI: 10.1016/j.jaad.2005.08.044
Disciplines
  • Medicine

Abstract

We describe the case of a 13-year-old boy with stage I hypopigmented mycosis fungoides in whom minimal residual disease was detected with T-cell receptor γ-polymerase chain reaction after the disease was in complete clinical remission. We further cloned and sequenced the T-cell receptor γ-polymerase chain reaction product of the lesion in remission and found that the original T-cell clone still existed in decreased amounts. The patient was followed up for 3 1/2 years without any new lesions developing. The clinical significance of this residual malignant T-cell clone in mycosis fungoides remains to be elucidated.

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