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Increased Urinary Levels Of Tamm-Horsfall Glycoprotein Suggest A Systemic Etiology of Interstitial Cystitis

Authors
Journal
The Journal of Urology
0022-5347
Publisher
Elsevier
Publication Date
Volume
156
Issue
3
Identifiers
DOI: 10.1016/s0022-5347(01)65668-4
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

Abstract Purpose We investigated the role of Tamm-Horsfall protein in interstitial cystitis. Materials and Methods Urinary Tamm-Horsfall protein excretion was analyzed in interstitial cystitis patients and controls, and bladder biopsy specimens were stained immunohistochemically for Tamm-Horsfall protein. Results Urinary Tamm-Horsfall protein levels in 28 women with interstitial cystitis were statistically significantly greater than those in 25 female controls. No positive staining for Tamm-Horsfall protein was demonstrated in the bladder tissue from 10 interstitial cystitis cases. Conclusions The results support the notion that interstitial cystitis may have a systemic etiology. In addition, this assay might have clinical value in the diagnosis of interstitial cystitis.

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