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Relationship between the cortical choline acetyltransferase content and EEG delta-power

Authors
Journal
Neuroscience Research
0168-0102
Publisher
Elsevier
Publication Date
Volume
8
Issue
1
Identifiers
DOI: 10.1016/0168-0102(90)90052-g
Keywords
  • Nucleus Basalis
  • Acetylcholine
  • Choline Acetyltransferase
  • Cholinergic Deficit
  • Delta-Power
  • Alzheimer'S Disease
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract Destruction of the nucleus basalis abolished normal spectral power only in the frontal cortex, where choline acetyltransferase (ChAT) activity was lower. In lesioned animals, delta-power was increased and alpha-power decreased. The increase in delta-power during immobility correlated with a reduction in ChAT activity. High-voltage spindles occurred more frequently after cholinergic denervation. The results suggest that spectral power and high-voltage spindle analysis might serve as a useful tool for evaluating the efficacy of pharmacological strategies aimed at alleviating the cholinergic deficit.

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