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Standardization of individual lung inflation and its effect on aerosol derived effective airway dimensions

Authors
Journal
Journal of Aerosol Science
0021-8502
Publisher
Elsevier
Publication Date
Volume
23
Identifiers
DOI: 10.1016/0021-8502(92)90455-5
Keywords
  • Lung Morphometry
  • Effective Airway Dimensions
  • Normalization
  • Lung Inflation
  • Lung Function Test

Abstract

Abstract A non-invasive aerosol method allows the determination of effective airway dimensions (EADs) as a function of volumetric lung depth (V LD). Anatomical methods have shown that airway morphometry is affected by body height, lung volume and lung inflation. This study was performed to investigate the effect of these parameters on aerosol derived EADs. In all subjects EADs were determined twice at two different lung inflations to allow normalization of EADs at 80 % TLC. The study group has been divided into two subgroups of low ( n=6) and high ( n=5) TLC and body height. Before normalization EADs of the two subgroups were not significantly different and no significant correlations between EADs and anthropometric data were found. The described differences and correlations got significant after normalization of EADs at 80 % TLC. The results confirm, that EADs are a function of anthropometric data and individual lung inflation and should be normalized.

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