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Surface simulation synthesis: A new strategy to spy α-helix structure

Authors
Journal
Vaccine
0264-410X
Publisher
Elsevier
Publication Date
Volume
25
Issue
36
Identifiers
DOI: 10.1016/j.vaccine.2006.09.064
Keywords
  • Surface Simulation Synthesis
  • α-Helix
  • Hiv-1
  • Gp41
Disciplines
  • Biology

Abstract

Abstract In key proteins, there are always some α-helix structures, which play important role in the structure and functions. Many epitopes lie on the surface of α-helix. These epitopes are not easy to be recruited into the vaccine development, because they are conformation dependent epitopes. Can such epitopes on α-helix be mimicked synthetically? Our findings undoubtedly validate the feasibility of surface simulation synthesis with short linear peptide to mimic the antigenic side of α-helix structure.

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