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Simple transformation of nitrile into ester by the use of chlorotrimethylsilane

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
39
Issue
51
Identifiers
DOI: 10.1016/s0040-4039(98)02143-1
Keywords
  • Esterification
  • Lactonization
  • Nitriles
  • Esters
  • Chlorotrimethylsilane

Abstract

Abstract Treatment of nitriles with alcohol and chlorotrimethylsilane at 50°C for 4 h could give esters in fair to good yields. Under similar reaction conditions, intramolecular lactonization via the concomitant nitrile and hydroxy groups in good yield were also demonstrated.

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