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Association of adenoma and focal nodular hyperplasia: experience of a single French academic center

BioMed Central
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  • Medicine

Abstract ral ss BioMed CentComparative Hepatology Open AcceResearch Association of adenoma and focal nodular hyperplasia: experience of a single French academic center Christophe Laurent1,3, Hervé Trillaud1, Sébastien Lepreux2,3, Charles Balabaud*1,3 and Paulette Bioulac-Sage2,3 Address: 1Fédération d'Hépato-gastro-entérologie, Hôpitaux Saint-André et Haut-Lévêque, France, 2Service d'Anatomie Pathologique Hôpital Pellegrin, CHU Bordeaux, France and 3GREF INSERM E0362 – Université Bordeaux 2, 33076 Bordeaux Cedex, France Email: Christophe Laurent - [email protected]; Hervé Trillaud - [email protected]; Sébastien Lepreux - [email protected]; Charles Balabaud* - [email protected]; Paulette Bioulac- Sage - [email protected] * Corresponding author Abstract Background: We report our experience of the simultaneous occurrence of adenoma and focal nodular hyperplasia (FNH). Liver cell adenoma together with FNH was found in five out of 30 cases of "multiple benign hepatocytic nodules" collected in our files of the Department of Pathology of the University Hospital of Bordeaux, during the last 12 years. All five cases were women on oral contraceptives. In all cases, the reason for surgery was the discovery, by imaging techniques, of an adenoma (4 cases) or of an unidentified benign tumor, possibly an adenoma. Results: Four cases of FNH were discovered by imaging techniques, prior to surgery. Additional small nodules were diagnosed either during surgery or during the slicing of the specimen in 3 cases. Adenoma and the FNH cases identified by imaging techniques were confirmed as such by light microscopy. Some small nodules could not be categorized with certainty because they contained biliary structures without ductular reaction. In one case, the non-nodular liver was abnormal around the area in which there were multiple nodules: there was approximation of portal tracts with portal and hep

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