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First total synthesis of (−)-dioncophylline A (“Triphyophylline”) and of selected stereoisomers: Complete (revised) stereostructure

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
31
Issue
5
Identifiers
DOI: 10.1016/s0040-4039(00)94589-1

Abstract

Abstract The first total synthesis of dioncophylline A (previously “triphyophylline”) and some selected stereoisomers is described, using an intramolecular-type mixed aryl coupling method via ester-type prefixed molecular moieties. Simultaneously, this synthesis establishes the complete (revised) stereostructure of dioncophylline A as 1a, which is thereby the first fully elucidated naphthylisoquinoline alkaloid of Dioncophyllaceae.

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