Affordable Access

Effects of α-tocopherol on platelet membrane function in cystic fibrosis

Journal of Laboratory and Clinical Medicine
Publication Date


Abstract Patients with cystic fibrosis and their parents were reported to have abnormal platelet aggregation responses to prostaglandin E 1. To determine whether this is a property of the platelets, we studied the adenosine 3′:5′-cyclic monophosphate (cAMP) response of washed platelets to prostaglandin E 1. The cAMP response to prostaglandin E 1 was the same in platelets from obligate heterozygotes for cystic fibrosis and from those of healthy controls. Patients with cystic fibrosis who had deficient vitamin E levels (plasma α-tocopherol, <500 μg/dl) had significantly (p < 0.01) reduced platelet cAMP response to prostaglandin E 1 compared with patients who had sufficient vitamin E, and supplementation with water-miscible vitamin E in these patients resulted in significant increases in plasma α-tocopherol levels (p < 0.01) and in cAMP response to prostaglandin E 1 (p < 0.05). Plasma α-tocopherol levels correlated significantly with platelet cAMP response to prostaglandin E 1 in patients with cystic fibrosis (r = 0.58, p < 0.05). However, plasma α-tocopherol level was unrelated to the lymphocyte and granulocyte cAMP response to prostaglandin E 1 or to the platelet cAMP response to α 2-adrenergic stimulation. Our data suggest that patients with cystic fibrosis have no inherited defect in platelet cAMP response to prostaglandin E 1. In patients who have sufficient vitamin E, cAMP responses to prostaglandin E 1 are normal in all the formed elements of the blood.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times