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Selective c-Jun overexpression is associated with ionizing radiation-induced apoptosis in the developing cerebellum of the rat

Authors
Journal
Molecular Brain Research
0169-328X
Publisher
Elsevier
Publication Date
Volume
38
Issue
1
Identifiers
DOI: 10.1016/0169-328x(95)00334-o
Keywords
  • Bcl-2
  • Bax
  • C-Myc
  • Fos
  • Jun
  • Apoptosis
  • Cell Death
  • Ionizing Radiation
  • Development
  • Nervous System
Disciplines
  • Chemistry

Abstract

Abstract Immunohistochemistry to Bcl-2, Bax, c-Myc, c-Fos, Fos-related, c-Jun, Jun B and Jun D was used to study the involvement of these factors in ionizing radiation-induced apoptosis in the cerebellum of the developing rat. Selective c-Jun overexpression was observed during the whole process of radiation-induced cell death. Furthermore, c-Jun overexpression was restricted to apoptotic cells, as shown by double labeling with the method of in situ labeling of nuclear DNA fragmentation and c-Jun immunohistochemistry. This is the first in vivo evidence that selective c-Jun overexpression is associated with apoptotic cell death in the developing nervous system following ionizing radiation.

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